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1、石河子大學(xué)碩士學(xué)位論文硫酸鎂在蛛網(wǎng)膜下腔出血后作用的初步探討姓名：郭偉申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：外科學(xué)指導(dǎo)教師：王業(yè)忠201106IIAbstractObjective：Toestablishasimplereliablecerebralvasospasmmodelaftersubarachnoidhemrhagethroughautologusarterialbloodinjectionintothecisternamagnatwice

2、inrabbit，afterMagnesiumSulfateInjectionwasinjectedintothemuscleweobservedthetransfmofNeuroethologicsceassessedthebloodflowrateofbasalarteryofrabbitthemphologicchangeofbasilararterywithhemotoxylineosinstainingInterleukin1

3、7ofbloodplasmaexpressionsofTransfminggrowthfactβ1infrontlobefollowingvasospasm.aftersubarachnoidhemrhagestudyingtheeffectofmagnesiumsulfateonInterleukin17ofbloodplasmaexpressionsoftransfminggrowthfactβ1infrontlobeinderto

4、expledeeplierpathophysiologicalmechanismthatmagnesiumsulfatecanrelieveVasospasmimproveNeuralfunctionprovidingmetheeticalbasisfthetreatmentwithmagnesiumsulfatewasusedinclinical.Methods:Afterestablishingautologusarterialbl

5、oodinjectionintothecisternamagnatwice.wechoose40whoisVasospasmbyexaminingwithTCDin60healthymaleNewZealwhiterabbitswhichwereradomlydividedintotwogroups，includingmagnesiumsulfategroupsalinegrouptwogroupswereequallyassigned

6、into5subgroupsaccdingtotimepoints1d3d5d7d14d（n=4）.On1d3d5d7d14d25%magnesiumsulfate(0.3mlKg.d)wasinjectedintothemuscleinthemedicinegroupeverydaythesamesalinewasinjectedinthesalinegroupweobservedNeuroethologicsceassessedth

7、ebloodflowrateofbasalarteryofrabbitthemphologicchangeofbasilararterywithhemotoxylineosinstainingweexaminedthetransfmofInterleukin17ofbloodplasmaexpressionsofTransfminggrowthfactβ1infrontlobefollowingvasospasm..Results:Ra

8、bitsoftwogroupsneuralactionbegintobedeclinefrom1daftersubarachnoidhemrhagedietmovementaredelineNeuroethologicsceoftwogroupsarenotdifference(P0.05)Damageofneuralactionofmagnesiumsulfate–groupislessthansalinegroupfrom3to14

9、neuroethologicsceofrabbitinsalinegroupbegintobeslowercomparedwithmagnesiumsulfate–group(P0.05)Theaveragebloodflowrateofbasalarteryisrisedfrom1ditishigheston7dthenisdelineto14dwhenvasospasmisexistinginmagnesiumsulfate–gro

10、upon3dbegintobeslowercomparedwithsalinegroup(P0.05)itwasdecresedobviouslyon7d(P0.01)basilararterycanbeseenthatendothelialcellsareincompletedelasticmembranceisdisttedintolumenendothelialcellsareswellingtwogroupsarenotsign

11、ificantdiffrencesthecontentofInterleukin17ofbloodplasmaisrisedfirstlyiitishigheston7dthenisdelinemagnesiumsulfate–groupbegintobeslowercomparedwithsalinegroup(P0.05)on3ditwasdecresedobviouslyon5d7d14d(P0.01)，transfminggro

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