卡巴膽堿對胎羊腎素血管緊張素系統(tǒng)影響的研究.pdf

1、蠶鑭文誓同等學力人員碩士學位論文(2008屆)卡巴膽堿對胎羊腎素血管緊張素系統(tǒng)影響的研究StudyontileeffectsofCarbaeholoilreninangiotensinsystemintheovinefetus研究生姓名指導教師姓名專業(yè)名稱研究萬向萬鎮(zhèn)茅彩萍圍產(chǎn)醫(yī)學生物學圍產(chǎn)藥理學論文提交日期!!堅圭l!旦Study0Btheeffects—o—fCa—r—bachol—o—n—r—eninang——iotensinsy

2、s—te—mintheov—i—ne——fetu——sAbstractStudyontheeffectsofCarbacholonreninangiotensinsystemintheovlneIetus●’●一AbstractObjective：CholinergiesystemplaysanimportantroleinthecontroloffetalcardiovascularandendocrineresponsesToinv

3、estigatethemechanismsthroughwhichthecardiovascularresponsescouldbe4nducedbYtheactivationoffetalcholinergiesystem，wefocusedonthechangesoffetalhormonalsystems，includingthereninangiotensinsystemMethod：，玎1epresentstudyusedch

4、ronicallypreparedovinefetalmodelundertheconsciousandunstressedconditionanddidinuterotestingforfetalsystolicpressure(SP)，diastolicpressure(DP)，meanarterialpressure(MAP)，heartrate(瑚R)，systolicdurationanddiastolicdurationIn

5、addition，bothmaternalandfetalbloodsampleswerecollectedbefore(duringbaselineperiod)andaftertheintravenousadministrationofcarbach01Simultaneously，thefetalplasmahormonelevels(includingAngI，AngII，AVP，INS，NO，eta1)weredetected

6、byimmunoradiologicalmethodBloodsampleswerealsoanalyzedbyNovaanalyzerforbloodpH，P02，PC02hemoglobinandhemotecritlevels，andtheconcentrationofplasmaglucose，lacticacid，NaandKwerealsomeasuredResults：Althoughintravenousadminist

7、rationofcarbacholhadnoeffectonplasmavasopressininsulin，andnitricoxideconcentrations，thisagonistcouldinduce趾elevationofangiotensinIandangiotensinIIlevelsintheovinefetalplasmInaddition，ovinefetalbloodvalues，includingsodium