胸水DNA倍體分析、癌胚抗原和鐵蛋白測定對惡性胸腔積液診斷價值的對比研究.pdf

1、南昌大學(xué)醫(yī)學(xué)院碩士學(xué)位論文胸水DNA倍體分析、癌胚抗原和鐵蛋白測定對惡性胸腔積液診斷價值的對比研究姓名：李強(qiáng)申請學(xué)位級別：碩士專業(yè)：內(nèi)科學(xué)（呼吸系統(tǒng)疾?。┲笇?dǎo)教師：馬琳20070601AbstractABSTRACTobjective：ToinvestigatethediagnosticvalueofDNAanalysiswithflowcytometryinmalignantpleuraleffusionsandevaluatethe

2、diagnosticvalueandclinicalfeasibilityofDNAanalysiscombinedtheCEAandSFdetectioninmalignantpleuraleffusionsMethods：Thebenignandmalignantpleuraleffusionsfrom78patientweredetectedbyDNAanalysisusingflowcytometryandwereexamine

3、dforCEAandSFlevelbyCLIAatthesametimeResult：ThesensitivityoftheDNAheteroploiddetectionwithflowcytometrywas8421％thespecificitywas80％，theYouden’SindexWas064，theaccuracywas82。05％andthepositivepredictivevaluewas80％Thesensitiv

4、ityoftheCEAdetectionwas6053％，thespecificitywas975％，theYouden’SindexWas058，theaccuracyWaS79，49％andthepositivepredictivevaluewas9583％強(qiáng)esensitivityoftheSFdetectionWas9474％，thespecificityWas50％，theYouden’SindexwasO45。theaccu

5、racywas7179％andthepositivepredictivevaluewas6429％Thereissignificantdifferenceinthesensitivity，specificityandpositivepredictivevalueamongthethreedetections(P005)TheDNAanalysisconnectstheCEAdetectioninparalleltest(Itssensi

6、tivitywas9377％，thespecificitywas78％，theYouden，Sindexwas072，theaccuracyWas8568％andthepositivepredictivevaluewas8019％)andcontactstheSFmethodsinseriestest(Itssensitivitywas7978％thespecificitywas90％，theYouden’SindexWas070，th

7、eaccuracywas8502％andthepositivepredictivevalueWas8834％)havebetterdiagnosticvalueformalignantpleuraleffusionsamongtheallcombinetestConelusions：DNAanlysisusingFlowCytometrytothemalignantpleuraleffusionsishighlysensitiveand