含有苯基側(cè)鏈的α-氨氧基酸的合成、構(gòu)象研究和應(yīng)用.pdf

1、丫7704379欠孥’碩士學(xué)位論文學(xué)扭代料10246一’≯：j：022022016含有苯基側(cè)鏈的a一氨氧基酸的合成、構(gòu)象研究和應(yīng)用院系：專業(yè)：姓名：指導(dǎo)教師：完成同期：化學(xué)系有機(jī)化學(xué)樊云飛楊月教授2005年5月10日AbstractKeywords：0caminoxyacid，phenylsidechain，N旬turn，chiralshiftreagentcarboxylicacid，catalyst，AldolreactionCLC

2、number：062Wehavesynthesizeda—aminoxyacidoligomerswithphenylsidechainmadstudiedtheirconformationWehavealsodevelopedtwotypesofcompoundsderivedfrom旺一aminoxyacidswithphenylsidechainandinvestigatedtheirapplicationinchiralreco

3、gnitionandasymmetricAldolreaction，respectivelyWehavesynthesizedchiralIXaminoxyacidswithphenylsidechaininhighopticalpuritystartingfromchiralmandelicacidviatwodifferentwaysTheconformationNstudies，byusingNMR，F(xiàn)T—IR，andCDspec

4、troscopicmethodsaswellasX—raycrystallographyhavedemonstratedthatpeptidescontaining程一anfinoxyacidswithphenylsidechainstilladopteightmemberedringintrarnolecularhydrogenbondsbetweenadjacentresiduesrcalledtheN一0turns)Wehavep

5、reparedaseriesofc2symmetriccompoundsderivedfromaaminoxyacidswithphenylsidechaininhi曲overallyieldsAseriesofchiralrecognitionstudiesindicatethatcompounds42cand43ehaveagoodabilitytorecognizeenantiomersofabroadvarietyofcarbo

6、xylicacidsinthe1HNMRspectraThusthesetWOcompoundscanbeusedaschiralshiftreagentsforthedeterminationofenantiomericpuritiesofchiralcarboxylicacidsby1HNMRdirectlyandrapidlyFrom僅一aminoxyacids、析thphenylsidechainwehavealsodevelo