含1，3，4-噻二唑環(huán)(及哌嗪環(huán))的吡唑甲酰胺類化合物的合成、結(jié)構(gòu)表征及生物活性研究.pdf

1、遼寧師范大學(xué)碩士學(xué)位論文含1，3，4噻二唑環(huán)（及哌嗪環(huán)）的吡唑甲酰胺類化合物的合成、結(jié)構(gòu)表征及生物活性研究姓名：牟萍萍申請學(xué)位級別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：安悅20090501含1，3，4噻二唑環(huán)(及哌嗪環(huán))的吡唑甲酰胺類化合物的合成、結(jié)構(gòu)表征及生物活性研究AbstractTodayheterocycliccompoundsespeciallyheterocyclic、歷t11”N”occupytheimportantpositio

2、nintheresearchanddevelopmentofpesticidePyrazolecompoundsisakindofveryimportantcompounds，whichhavegoodbiologicalactivityandusedwidelyinthefieldofcoordination，agriculture，medicineandcoordinationchemistryBecauseofitss眥眥of’N

3、C—S”，1，3，4一thiadiazolecompoundscanbeusedasbiologicalactivitycenterchelatingsomemetalions謝thgoodpermeabilityandcanplayabettereffectinweeding，plantgrowthregulating，sterilization，insecticidal，etcInaddition，theapplicationsin

4、pharmacologicalarearousedgreatinterestPiperazinederivativeshavealsoattractedmoreandmoreattentionduetotheirexcellentactivitiesnlesynthesisandactiveresearchofthecompoundscontaininganyheterocyclichavebeenreported，butitisrar

5、eaboutcompoundswithpyrazolesringand1，3，4thiadiazolering，andfewaboutcompoundswith3kindsofaforementionedheterocyclic4substitutedacetophenoneanddiethyloxalatewereusedasthestartingmaterials，basedonthemethodsofClaisencondensa

6、tion，Knorrcyclization，methylation，chlorination，hydrolyzationtheester5pyrazolecarboxylicacidswereobtained，andthen5kindsofacylchlorideweresynthesizedwithpyrazolecarboxylicacidsandthionylchloride；6kindsofl，3，4thiadiazoleder

7、ivativeswerereceivedfromsubstitutedcarboxylicacidsandthiosemicarbazideusingphosphorusacylchlorideasthedehydratingagentPyrazole，1，3，4一thiadiazolewereconnectedtogetherthoughacylamidationreactionand30targetcompoundswhichhav

8、enotyetbeenreportedintheliteraturesweresynthesizedT11eaminoin2一amino5(4nitrophenyl)一1，3，4一thiadiazolewerechlorinatedfirstlytheobtainedcompoundreacted晰tllpiperazine，andthencombined謝ththepyrazoleacylchloride，5newtargetcomp

9、oundswerereceivedcontainingpyrazole，13，4一thiadiazoleandpiperazineAC02’。coordinationcompoundsweregotthroughintermediateproductscoordinatedwithtransitionmetalionsAllthetargetcompoundsandintermediateswerecharacterizedbyIR，N

10、MRArepresentativecompoundWascharacterizedinthe2DforfurtherstudyingthestructuresofthetargetcompoundsInordertoconfirmthestructuresofnewcoordinationcompound，itsstructIJrewascharacterizedbyX—raysinglecrystaldiffractionmeasur

11、ementBesides，primarybiologicalactivityexperimentshavebeendonetoallthetargetcompoundsItisfoundfromtheresultsthattheactivitiesofallthetargetcompoundswerenothighand6ofthemwereantiblastictowheatgemmaintheconcentrationof10ppm