NP和DP方案聯(lián)合放射序貫治療非小細(xì)胞肺癌放射性肺炎發(fā)生率的比較及臨床分析.pdf

1、中南大學(xué)碩士學(xué)位論文NP和DP方案聯(lián)合放射序貫治療非小細(xì)胞肺癌放射性肺炎發(fā)生率的比較及臨床分析姓名：張依然申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：內(nèi)科學(xué)腫瘤指導(dǎo)教師：曹培國(guó)20090501七年制碩士學(xué)位論文摘要ABSTRACTObjeetives：Toinvestigatetheincidenceofradiationpneumonitis(RP)ofnonsmallcelllungcancerpatientsaftertreatmentofdiffe

2、rentregimesofsequentialchemoradiotherapyMethods：RetrospectiveanalysiswasusedtostudytheincidenceofRPof249NSCLCpatientswhoreceivedNPorDPchemotherapyplusradiotherapyintheThirdXiangyaHospitalfromSep2002toSep2008Alldatawerepr

3、ocessedbySPSS170Statisticanalysismethodsincludingstatisticdescription，Chi—squareanalysis，multivariateanalysisperformedusingLogisticregressionmodelResults：(1)Theincidenceofradiationpneumonitis(grade芝_2)was542％Itoftenoccur

4、red13monthsafterradiotherapy(541％)Themediantimewas2monthsMostradiationpneumonitiswereofgrade2(622％)(2)Amongthe249cases，theincidenceofRPinNPregimewas497％，withgrade2651％，grade3301％，grade448％，grade5O％AndtheincidenceofRPinDP

5、regimewas634％，withgrade2577％，grade3404％，grade419％，grade5O％TheincidenceofRPwashigherinDPregimethanthatinNPregime。theyweresignificantdifferent(P005)(3)Logisticregressionanalysisindicatedthathistoryofcardiovasculardiseaseor

6、basiclungdisease，radiationdose，radiationfieldsizechemotherapeuticregimeandcyclesofchemotherapywereindependentinfluentialfactorsofRP(130，I汛l，P005)Andradiationdose，radiationfieldsize，chemotherapeuticregime，cyclesofchemothe

7、rapyhadanobviousimpactontheincidenceofRP(P001)TherelativeriskofRPWashigherinDPregimethanthatinNPregimewhenotherfactorsfixedConclusions：TheincidenceofRPwashigherinDPregimethanthatinNPregimeButtherewasnosignificantdifferen