胃腸道間質(zhì)瘤中ki-67、PCNA和MCM2蛋白的表達(dá)及臨床意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文胃腸道間質(zhì)瘤中ki67、PCNA和MCM2蛋白的表達(dá)及臨床意義姓名：董潔晶申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：普通外科指導(dǎo)教師：閆軍20100415山西醫(yī)科大學(xué)碩上學(xué)位論文Expressionofki一67、PCNAandMCM2inGastrointestinalStromalm1o1‘‘1oo一’lUmOrSand1tSC上1n1CalS19nltlCanCeAbstractObjectiveToinvestigatet

2、heexpressionofki一67、PCNAandMCM2proteiningastrointestinalstromaltumors(GISTs)anditsrelationshipwiththeinvasiverisklevelMethods26GISTsweregroupedinto10w—risk，intermediate—riskandhigh—riskTheexpressionofki一67、PCNAandMCM2pro

3、teinweredetectedin26GISTand10normaltissuesfromthedistalresectionmarginofc010rectalcancer(contr01group)byimmunohistochemicaltechnique，andquantifiedki一67、PCNAandMCM2protein’sexpressionbycalculatingalabelingindex(LI)TheLIof

4、thethreeproteinsineverygroupwerecompared，andananalysisoftheassociationbetweenthethreeDroteinsandtheinvasiverisk1evelofGISTswasalsocarriedoutResults(1)TheLIofki一67、PCNAandMCM2inGISTsgroupwere15％(O％～70％)、325％(o％～80％)、30％(0

5、％～90％)respectively，andtheywere5％(o％～10％)、17％(0％～25％)、15％(0％～20％)respectivelyincontr01groupThedifferencesbetweenthetwogroupswerestatisticalsignificance(PO05)(3)TheexDressionofki一67、PCNAandMCM2wereassociatedwithinfiltratio