24877.風(fēng)疹病毒宿主細(xì)胞受體的研究

1、中國(guó)科學(xué)院研究生院博士學(xué)位論文風(fēng)疹病毒宿主細(xì)胞受體的研究姓名：叢浩龍申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：微生物學(xué)指導(dǎo)教師：田波2011IdentificationoftheGlycoproteinasaMyelinOligodendrocyteCellularReceptorforRubellaVirusAbstractRubellavirus(RV)isahighlytransmissiblepathogenicagentthatcausesth

2、ediseaseofrubellaRVconsistsofapositive—sense，single—strandedRNAgenomeenclosedinaquasisphericalcapsidandanenvelopeinwhichthetwotypeImembraneglycoproteins，E2andEl，areembeddedasaheterodimericspikecomplexTheclinicalsymptomso

3、fRVinfectionsacquiredpostnatallyareusuallymild，butmaternalinfectionduringthefirst8weeksafterthelastmenstrualperiodresultsinchronicnon—lyticinfectioninnearlyallfetuses，withalmostallinfectedfetusesdevelopingcongenitaldefec

4、tswhichentailsarangeofseriousincurableillnessesincludecardiac，cerebral，ophthalmicandauditorydefectsSpecificinteractionofvirionconstituentswithcellularsurfacecomponentsisessentialforinfectionoftargetcellsbyextracellularvi

5、rusparticlesForenvelopedviruses，suchasrubellavirus，thisprocessismainlymediatedbythespecificbindingofenvelopeproteinsofthevirusestocellreceptors，resultingintheattachmentofvirusparticlestothecellThoughmostevidenceindicates

6、thatafterattachmenttheRVisinternalizedtoanendosomevacuolebythefusionoftheviralenvelopetotheendosomalmembranefollowingconformationalchangesintheRVE1andE2glycoproteins，therouteandmechanismofRVentryintothehostcellisnotcompl