FSAP基因的MarburgⅠ型多態(tài)性與腦梗死發(fā)病的相關(guān)性研究.pdf

1、中南大學(xué)碩士學(xué)位論文FSAP基因的MarburgⅠ型多態(tài)性與腦梗死發(fā)病的相關(guān)性研究姓名：譚倩申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：內(nèi)科學(xué)（血液病學(xué)）指導(dǎo)教師：陳方平20090501碩士學(xué)位論文英文摘要ABSTRACTObjective：ThefactorVII—activatingprotease(FSAP)isanovelplasma—derivedserineprotease，whichconsistsofthreeepidermalgrowth

2、factor(EGF)一likedomains，akringledomain，andaserineproteasedomainTheMarburgIpolymorphismofFSAPlocatingintheserineproteasedomainresultsinsignificantimpairmentnotonlyintheprourokinaseactivatingpotency，butalsointheproteolysis

3、potencyofFSAPtotheplateletderivedgrowthfactorBB(PDGFBB)，thebasicfibroblastgrowthfactor(bFGF)andthevascularendothelialgrowthfactor(VEGF)Asaresult，theinhibitoryactionofFSAPtothesecytokine—mediatedproliferationandmigratatio

4、nofthevascularsmoothmusclecell(VSMC)andtheendothelialcellwillbeweakenedAllthefunctionalimpairmentwillacceleratethedevelopmentofangiosclerosisandarterialstenosisprocessThereareanumberofaboardreportscharacterizedthattheMar

5、burgIpolymorphismofFSAPisrelatedwithawidevarietyofthrombusdiseasesAsathrombus—relateddisease，cerebralinfarction’smainpathologicalchangesistheformationofvascularthrombosisonthebasisofthecerebralarteriosclerosis，whichblock

6、bloodflowandresultinbrainischemia，hypoxiaandnecrosisAndthefunctionalimpairmentoftheFSAPMarburgImutantcancauseoraggravatethesepathologicprocessesintheoryHowever，thereisnoresearchabouttherelationshipbetweenFSAPMarburgIpoly

7、morphismandcerebralinfarctionOurobjectiSthefirsttimetoexploretheclinicalrelationshipbetweenFSAPMarburgIpolymorphismandcerebralinfarction，andanalysiswhetheritisoneoftheriskfactorsofcerebralinfarctionMethods：Thesinglestran

8、dconformationpolymorphism—polymerasechainreaction(SSCPPCR)wasemployedforthepolymorphismanalysisofFSAPgeneinpatientswithcerebralinfarctionandage，sexmatchedvolunteerswithoutthrombusrelateddiseaseshistoryTheFisherprobabilit