PLGA-明膠電紡纖維膜及其表面仿生礦化的研究.pdf

1、天津大學(xué)碩士學(xué)位論文PLGA明膠電紡纖維膜及其表面仿生礦化的研究姓名：趙玉平申請學(xué)位級別：碩士專業(yè)：材料學(xué)指導(dǎo)教師：袁曉燕20080601ABSTRACTElectrospinningisaneffectivewaytofabricateultrafinefibersWithhighspecificsurfaceareaandhighporosity，electrospunfibrousmembranescanbeusedintissu

2、eengineeringElectrospunmembranesofsyntheticandnaturalpolymerblendscombinetheadvantagesofboth，forexample，theexcellenttensilepropertiesoftheformerandgoodbiocompatibilityofthelaaerEiectrospunmembranescanbeusedasmatricesofbi

3、omimeticmineralizationtoproduceceramic／polymercompositematerials，whichareabletomimicnaturalboneintheaspectsofcomponentandstructureInthisstudy，highlyporouselectrospunmembranesofPLGA／gelatinblends(PLGA／GEL)wereusedasmatric

4、esforthemineralizationofsyntheticCa—Pcompoundsintentimesimulatedbodyfluid(IOSBF)FibrousmembranesofPLGAandPLGA／GELwithpercentageof1％，5％，10％，15％wereproducedviaelectrospinningThemorphologiesofultrafinefiberswereinvestigated

5、byscanningelectronmicroscopeandtransmissionelectronmicroscopeStudiesonGELreleasedbehaviorswereprocessedbyimmergingPLGA／GELmembranesinfreshphosphatebufferedsaline(PBS)Attheearlystage，theburstreleasesofallmembraneswereobvi

6、ouslyobservedAfter1d，thereleasepercentageswas20％30％and21dlater，thefinalreleasepercentagesforPLGA／GELmembraneswerenearly75％90％PLGA／GELmembraneswerecrosslinkedbyglutaraldehyde(GA)underroomtemperaturefor1dThewateruptakeandm

7、echanicalpropertiesofPLGAandPLGA／GELmembranesbeforeandaftercrosslinkingweremensuratedTheresultsshowedthatcomparedtoPLGAmembrane，thewateruptakeofPLGA／GELmembraneswereincreasedduetotheintroductionofGELcomponent；however，cro

8、sslinkingreducedthewateruptakesofPLGA／GELmembranesThemechanicalpropertiesofelectrospunmembraneswereevaluatedbytensiletestandtheresultsindicatedthatthePLGA／GELmembraneswith1％or5％GELbeforecrosslinkingshowedsimilartensilest

9、rengthesandYoung’SmoduliwithPLGAmembranesbuthigherelongationindrystate；aftercrosslinkingeverymembraneshadhighertensilestrengthandYoung’SmodulusEachmembraneshowedworsetensilepropertiesinwetstatethanindrystateTheelectrospu

10、nPLGA／GELscaffoldswereusedasmatricesformineralizationofcalciumphosphateThemineralizationprocesscouldbeinitiatedbyimmersingtheelectrospunscaffoldin10SBFforvaryingperiodsoftimeScanningelectronmicroscopy(SEM)，energydispersi