血管緊張素轉(zhuǎn)化酶抑制藥物離子色譜法分析研究.pdf

1、桂林理工大學(xué)碩士學(xué)位論文血管緊張素轉(zhuǎn)化酶抑制藥物離子色譜法分析研究姓名：周丹申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：材料工程指導(dǎo)教師：朱巖20120401AbstractWththeincreasingimprovementofthepeople’Slivingstandard，thediseaserateofhypertensionincreasedswiftlyDamnificationofsometargetorgans(heart，testis

2、)causedbyhypertensionhasseriouslyaffectedthepatients’healthTherefore，itisnecessarytocontrolandtreathypertension，cardiovascularandcerebrovasculardiseasesPresently，therearesixmajorkindsofdrugsinmarkettOCurehypertension：(1)

3、diureticantihypertensiveagent；(2)lBreceptorblockers；(3)angiotensinconvertingenzyme(ACE)inhibitors；(4)angiotensinIIreceptorblocker(ARB)；(5)calciumantagonists；(6)aadrenergicreceptorblockers。Amongthesedrugs，ACEIshares30％int

4、hetreatmentofhypertensionandhasbeeninuseforthelast20yearsinclinicaltreatmentIthaslittlesideeffectbutbecomesthefirstchoiceforthetreatmentofheartfailureandhypertensionThisthesisisdevotedtodevelopanewsimpleanalyticalprocedu

5、resforthedeterminationofninepharmaceuticallyimportantdrugsbelongingtothegroupofangiotensinconvertingenzymeinhibitors，namely，captopril(CP)，hydrochlorothiazide(HCT)，(IMI)，lisinopril(LSP)，ramipril(RMP)，benazeprilHCI(BZL)，fo

6、sinoprilsodium(FSP)andametaboliteenalaprilat(ENT)ThedrugsarenowadaysmassivelyadministratedduetotheirefficacyThedevelopedmethodshavebeenappliedforthedeterminationofsuchaclassofdrugsintheirlawmaterialsandpharmaceuticaltabl

7、etsaswellasinspikedhumanplasmaandurineDuetodevelopmentofionchromatographyitplaysanimportantroleinanalysisofdrugs，syntheticintermediates，identificationofaparticularcomponentinthecomplexcomponents，speciationanalysisofpharm

8、aceuticalionsInthisthesis，asimpleandhighlyselectivemethodfordeterminationof9kindsofACEIbyionchromatographywithUVdetectionhasbeendevelopedThemethodproposedisbaseduponionizationofthesedrugsinacidmediumtobewellretainedwitha

9、cationexchangecolumnThisleadstomuchimprovementoftheirpeakprofileswhichpermitstheiranalysisatnormaltemperatureandordinarypHThedevelopedprocedurewasappliedforsimultaneousanalysisofthestudieddrugsintheirtabletsandhumanplasm

10、awithsatisfactoryresultsThemethodprovedsuccessfulfordrugroutineanalysissavingtime，effortandelaborationInthisthesis，thefollowingcontentsareincluded：1Chemicalproperties，pharmacologyandreportedanalyticalmethodsonangiotensin