29176.硫代酰胺的成環(huán)反應(yīng)研究及其新型合成方法

1、學(xué)校代碼：10270學(xué)號(hào)：112200826分類號(hào)：062上夠腳范夫誓碩士學(xué)位論文論文題目硫代酰胺的成環(huán)反應(yīng)研究及其新型合成方法學(xué)專院生命與環(huán)境科學(xué)學(xué)院業(yè)有機(jī)化學(xué)研究方向有機(jī)合成研究生姓名杜培樂指導(dǎo)教師劉國華教授完成B期2014年4月二海師范大學(xué)碩_j學(xué)位論文ThioamideiSaveryimportantclassoforganicsulfurcompoundsItseasysynthesis，easypurification，no

2、peculiarsmell，andhighstability；duetothesulfuratomelectronegativity，extranucleardistributioncharacteristicsmakethenatureofthesecompoundsthanthecorrespondingamideandlively，withacolorfulrangeofchemicalpropertiescanbeconvers

3、ionreaction，causingitsgreatattention，especiallyinthestudyofthebiologicalactivityofacompoundInrecentyears，thestudyresultsindicatethatthebiologicalactivityofthioamidecompoundsiSwidelyusedCanbeusedforantiinflammatory，antise

4、pticandantiTB，butalsoasaclassofcompoundsofspecialreagentsorintermediates。ThefirstpartNallylbenzothioamideandferricchlorideastheresearchobiect，throughintramolecularcyclizationreactionSynthesisof5chloro3phenyl45dihydrothia

5、zoleThereactionconditionswereoptimizedsystemThestudyfoundthatthekindofLewisacid，Lewisacidequivalents，reactiontime，temperatureandadditivefactorshaveasignificanteffectonthereactionHowevertheyieldofthisreactionislowtoextend

6、theapplicationandsubstratereactionbroughtsomelimitmionsOverall。theNallylbenzothioamidecyclizationopenedupanewwaytodevelopanapproachbasedonferricchlorideeffectofintramolecularcyclizationthioamideThesecondpartmainlythioami

7、deandnitrogenhalidereagentsforthestudy，byintramolecularcyclizationThioaceamideThereactionconditionswereoptimizedsystemThestudyfoundthatthenitrogenspeciesofthehalogenatingagentthetypeofthethioamide，thetypeofsolventandtemp

8、eratureconditionsoffactorshaveasignificanteffectonthereactionExtensioninthesubstratefoundthatthereactionhasarelativelygoodselectivityandhighyieldIngeneral，thedevelopmentofactionunderanitrogenhalidereagentsbasedonintramol

9、ecularcyclizationThioaceamideThismethodstepissimple，convenientandefficient，highlyselectivebuildareaof4，5dihydrothiazolecompoundsThethirdpartteflecttheamideandorganicsulfurreagentsforthestudy，bythioamidesynthesisreactions

10、OurreactionconditionswereoptimizedsystemThestudyfoundthatthetypeoforganicsulfurthetypeofsolventandreactiontimeandtemperatureconditionsfactorshaveasignificanteffectonthereaction，theadvantagesofthisreactionareundermildcond

11、itions，theuseofstable，easytostoreanddoesnottasteoforganicsulfurcompoundsReactionsforthesynthesisofthioamideopenedupanewwaytodevelopanorganicbasesaltbasedrole，atroomtemperature，thioamidecompoundrapidpreparationmethodKe)’w