Her-2-neu和NF-κBp65在胃癌中的表達(dá)及其臨床意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文Her2neu和NFκBp65在胃癌中的表達(dá)及其臨床意義姓名：安杰申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：外科學(xué)指導(dǎo)教師：趙浩亮郭建昇20100521山西醫(yī)科大學(xué)碩士學(xué)位論文ExDressionandclinicalsignificance0fHer2／neuandNFKBD65inEXDreSSlonannCllnlCalSlgnlIlCanCe0IHer—Z，neUanQ一量I。一KBDO，lngastricCarcinom

2、aAbstractObjectiVe：1’odetecttheexpressionofHer2／neuandNF—KBp65ingaS仃iccarcinomatissue，t0eXploretlleirrelationship鋤dtlleroleingaStricc鋤cerfomlation，鋤dtherelatiollSllip誦tllclinicop甜lologiccharacteristicing砌ccarcinomaMethod

3、：Tbcollect80c嬲esofgaLstriccarcinoma觚d30caSesofno姍algastrictissueint11efirsthospital緬liatedofSh觚XiMedicalUniVerS時(shí)五『om20071to200812T0d酏ecttl地expressionofHer2／neu鋤dNF一心p65ingaStriccarcinomabyinununollistocheIIlis訂yassay(PV9

4、000)鋤dt0鋤1)rzetllerelationsllip謝tllcl誠copathologicch娥屺teristicing神iccarcinomaResult：1kpositiVerateofHer2／11eueXpressioningaStriccarcinomatissue、^，嬲225％(18／80)觚dinno衄砒tissue、糯33％(1／30)，tllereissigIlific鋤tdi恐rencebetweentl

5、lem(P005)T11ere、vaSnosi嘶fic枷di虢rence鋤ongtheexpressionofHer2／neuindi疏rentsex、ages、tlJIIlorsiZe、location、invaSiondepm、m蛐is觚dTNMstagesofthec鋤cer，wllileaSsociatevvitllde伊eeofhistodi婦鳧rentiation鋤Idlymphmicmet嬲tasis(P005)nlepo

6、sitivemteofNF一1cBp65expressioniIlg礎(chǔ)iccarcmInatissue、幡6125％(49／80)肌dinnomaltissuewaS267％(8／30)，nlereissi鰣fic鋤tdi仃erencebe№enthem(PO05)Therewasnosi螄fic肌tdi疵rence鋤ong恤expressionofNF心p65i11di腩rent辯x、ages、tllIIlorsize、locatio

7、n、metast撕sandTNMStagesoftIlecaIlcer，Ⅵ舡leaSsocia_te砒hde鏟eeofKstodi刪ation、m勰ionde呻鋤dl卿haticmetastaSis(PO05)Her2／neuisposi帆lyconelatI甜謝mNFKBp65ingastricc鋤certissue(r=O244，PO05)ConclusionHer2／neuandNF一1cBp65werehigmyexpresse