HIF-1a在急性高眼壓大鼠視網(wǎng)膜上的表達及青光靈改善視網(wǎng)膜缺氧狀況的研究.pdf

1、山西醫(yī)科大學碩士學位論文HIF1a在急性高眼壓大鼠視網(wǎng)膜上的表達及青光靈改善視網(wǎng)膜缺氧狀況的研究姓名：王卓偉申請學位級別：碩士專業(yè)：眼科學指導教師：馬蕾20070515山西醫(yī)科大學琢士學位論文TheexpressionofHIFIainretinainratsofacuteelevationinintraocularpressureandtheeffectofimprovingthesituationofhypoxiainretinao

2、fQingGuangKingAbstractobjectiv鐘低presentinvestigationw鵠designedtoexploretheprotectiontetinaofatraditionalChinesemedicineQmgOuangg洫gandtheexpressionofHIFlainn加inratsofacuteelevationinintraocularpressureMethods：90rats懈divid

3、edintOsixgroups(15ineach)normalcontrol(A)，modelcontrol(B)’highdoze(C)，middledoze(E)’lowdoze(F)’andYinmikang(F)Allm忸ineverygroupWereirrigatedintostomachbyI刪ivemedicineforseV舶daysAfterthatthemrsofgroupB，C，D，E，F(xiàn)w啪madeintoac

4、uteocularhypertensionmodelsTheacuteocularhypertensionmodelsWel“eestablishedbyforcingperfusionofnormalsalinesolutionintoanteriorchambermaintained60minutesandthetensionwas120ramHeOTheneachgroupw勰irrigatedintostomachcontinu

5、ouslyAndthentheratswereeuthanatizedatld2d3d7d，14dafterperfusionTheireyesw骶enucleatedforHEandHIFIaimmunohistochemisuyResults：1Morphologyresults：ThelevelofedemaofCFgroupwaslowerthanthatofmodelcontrolgroup(B)2In姍unohistoche

6、mistryresults：TheexpressionofHIFIawasnotdetectedinnormalcontrolgroupTheexpressionofHIFlawasincreasedsignificantlyinmodelcontrolgroupatldandthendecreasedgraduallyTheexpressionofHIFIainCFgroupwassignificantlydifferentwithm

7、odelcontrolgroup’Conclusions：ln培increasingexpressionofHIFlainretinainratsofacuteelevationinintraocularpressuresustainedthetheoryofhypoxinindamageofopticnerveofglaLI∞m丸2Qingguangkingcoulddecreasethelevelofedemainretinaofa