兔動(dòng)脈壁剪切力的改變對(duì)管壁基質(zhì)金屬蛋白酶2的表達(dá)以及動(dòng)脈瘤形成的影響.pdf

1、中南大學(xué)碩士學(xué)位論文兔動(dòng)脈壁剪切力的改變對(duì)管壁基質(zhì)金屬蛋白酶2的表達(dá)以及動(dòng)脈瘤形成的影響姓名：劉晟申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：外科學(xué)（血管外科）指導(dǎo)教師：舒暢20060501堡主堂垡笙壅—至篁盟哩ABSTRACTObjective：Toobservetherelationbetweenthechangeofthehemalwallshearstressandtheexpressionofthematrixmetalloproteinase2

2、(MMP2)andanalyzeitsroleinaneurysmformationMethods：48NewZealandrabbitsweredividedinto4experimentand4comparisongroupsaveragelyDuringtheoperationoftheexperimentgroups，ahomogeneitypatchwasimplantedontheabdominalaortatoforman

3、aneurysmfactitiouslywhileshamoperationsweredoneinthecomparisongroupsThearterialwallwasharvestedafter1day7days，14days，and28daysrespectivelyThediametersoftheaortaweremeasuredafterpatchingandbeforeharvestThelevelchangeofMMP

4、2wasobservedbyimmunohistochemistryandcomputerskillsResults：Thediametersoftheaneurysmanditsinflowoutflowwayswereenlargedinthe7daysgroupatthesacrificetime(p005)，andthevaluewasgrowingwiththetime；largeamountofinflammatorycel

5、lssoakagedthehemalwall，andelasticityfiberbrokedown；statisticsofalltheresuItsshowedthatIVlMP一2hadreachedthepeakvalueintheldaygroup(p001)，andremainedahighlevelexpressioncontinually(p001)Conclusions：Whenshearstressalters，th