CARD11、Bcl-2和NF-κB在彌漫性大B細胞淋巴瘤中的表達與意義.pdf

1、南昌大學醫(yī)學院碩士學位論文CARD11、Bcl2和NFκB在彌漫性大B細胞淋巴瘤中的表達與意義姓名：左云海申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：路名芝20080501AbstractABSTRACTObjective：TostudytheexpressionandsignificanceofCARDll、Bcl2、NFKBinthecommonimmunologytypesofdiffuselargeBcelllympho

2、maandexploretheeorrelativityduringthemMaterialsandMethods：60specimensofdiffuselargeBcelllymphomapatientsand20specimensofreactivehyperplasialymphnodewercselected，CARDll，Bcl2andNFrBwerestudiedbyusingtissuechiptechniqueandt

3、heMaxVisionimmunohistochemicalmethodsResults：OThepositiveratesofCDl0，Bcl6，MUMlandCDl38in60specimensofdiffuselargeBcelllymphomapatientswere300％、583％，583％and17％respectively(爹In60specimensofdiffuselargeBcelllymphomapatients

4、immunologytype：GCB25cases，ABe35cases14CaseshadtheprofleCDl0()／bcl6()and11caseshadtheprofileCDl0()mcl6()，21caseshadtheprofileCDl0()／Scl6()，13caseshadtheprofileCDl0(一)／bd一6()／MUMl()／CDl38()and1easehadtheprofileCDIO(一)／Bd6(

5、)／MUMl()／CDl38()③In60specimensofdiffuselargeBcelllymphomapatientsImmunologytype：GCB25cases，ABe35casesGCB25cases，thepositiveratesofCARDllwas240％ABe35cases，thepositiveratesofCARDllwas574％，therebeingsignificantdifferencebet

6、weenthetwogroups(P005)；GCB25Cases，thepositiveratesofBcl2was320％，ABe35cases，thepositiveratesofBcl2was629％，therebeingsignificantdifferencebetweenthetwogroups(PO05)；GCB25cases，thepositiveratesofNFKBwas280％，ABe35cases，thepos

7、itiveratesofNFKBWas686％，therebeingsignificantdifferencebetweenthetwogroups(PO05)；ThepositiveratesofBcl2inCARDllpositiveandnativespecimenswere808％、265％respectivelytherebeingsignificantdifferencebetweenthetwogroups(P005)Th

8、epositiveratesofBcl2inNF—KBpositiveandnativespecimenswere581％、41O％respectivelytherebeingsignificantdifferencebetweenthetwogroups(PO05)ThepositiveratesofNFKBinCARDllpositiveandnativespecimenswere769％、324％respectivelythere