胃癌c-fos表達(dá)及其與臨床病理預(yù)后特點的關(guān)系及NRS-2002評價胃癌患者圍手術(shù)期營養(yǎng)風(fēng)險的初步探索.pdf

1、北京協(xié)和醫(yī)學(xué)院博士學(xué)位論文胃癌cfos表達(dá)及其與臨床病理預(yù)后特點的關(guān)系及NRS2002評價胃癌患者圍手術(shù)期營養(yǎng)風(fēng)險的初步探索姓名：張杰石申請學(xué)位級別：博士專業(yè)：臨床醫(yī)學(xué)指導(dǎo)教師：于健春周立20090601Abstractobje嘶e：Toevaluatecorrelationsbetwe既灑sexpressionandpati饑ts’clinicopathologicalfactorsandprognosisingastriccalle

2、elMethods：Atotalof58patientswithgastriecancerunderwentsurgicalresectionfromJun2002t0Jan2003wereincludedExpressionofcfosintumorandparatumortissueswasdeterminedbyimmunohistochemistryTherelationshipbetweenclosexpressionandc

3、linicopathologicalandprognosticvariableswereevaluatedResults：Theexpressionratiosofclosintumorandparatumortissueswere672％and638％，respectivelySimultaneouslypositiveornegative爭toseXpressionintumorandparatumortissuesoccurred

4、in44patients(759呦‰orswithpositiveexpressionofefosintumortissuescarriedsmallersizeand10wefr縱eoffull1ayerinfiltrationUnivariateanalysisshowedthatpati鋤tSwithpositiveelosexpressionintumortissueshadsignifieantlyprolon窒∞overal

5、landtumorfreesurvival，comparedwiththosewithnegativeexpressionCoxregressiontestrevealedthatclosexpresslonm鋤ortissueswasofpotentialindependentprognosticimplicationExpressionofefosinparatumortissueswasnotcorrelatedwlthclini

6、copathologicalvariablesandpatientprognosisConelusions：OurdatademonstratedthatcloswaspositivelyexpressedinbothtunloralldparatumortissuesBesides，cfosexpressionintumortissuesw弱consistentwimthatinparatumortissuesThefindingsi

7、ndicatedthatefosmimbeinvolvedintumorigenesisofgastriccancerTumorswithofospositiveexpressionwereoflessprogressionextents，suggestingmeinllibitoryefleetofcfosinprogressionofgastriccancerFinallyelosl，ositiveexpressionintumor