乳腺癌雌孕激素受體表達預(yù)測新輔助化療敏感性的研究.pdf

1、浙江大學(xué)醫(yī)學(xué)院碩士學(xué)位論文乳腺癌雌孕激素受體表達預(yù)測新輔助化療敏感性的研究姓名：陳杰申請學(xué)位級別：碩士專業(yè)：臨床醫(yī)學(xué)指導(dǎo)教師：黃建20090501巍淡犬學(xué)碩士學(xué)毽論文茭文褰要，Predictingtheresponseofthepatientswith!ocailyadvancedbreastcancertoneoadiuvantchemothgrapybyER浙江大學(xué)醫(yī)學(xué)院碩士研究生導(dǎo)師腫瘤學(xué)陳杰黃建AbstractObjective

2、ToinvestigatewhethertheexpressionsofERand／orPRcouldpredictthesensitivityofneoadjuvantchemotherapyinpatientswithbreastcancersMethodsAll144patientswithbreastcancersreceivedneoadjuvantchemotherapyTheERandPRexpressionsoftumo

3、rsweredeterminedpreoperativelybyimmunohistochemistryTherelationshipofER／PRstatus賊mresponseratetoneoadjuvantchemotherapyWasthenevaluated。ResultRespomeratesofER(一)andER()tumorstoneoadjuvantchemotherapywere8391％and5789％；PR(

4、)andPR()were8085％and6000％respectivelyThesignificantdifferenceswereobservedbetweenER()VSER()(f=ll。997，P005)andPR()VSPR()(Z=7305，P005)Theresponserateintumors州thERandPRabsenttumorsWassignificantlyhigherthanthatinERand／orPRp

5、ositive(x2=9526，P005)ConclusionERand／orPRnegativebreastcancersweremoresensitivetoneoadjuvantchemotherapywhichindicatedERandPRmightbepredictivemarkersofneoadjuvantchemotherapy[KeyWordslBreastcancer；NeoadjuvantChemotherapy