血清CEA、CYFRA21-1對(duì)非小細(xì)胞肺癌輔助化療患者的預(yù)后意義.pdf

1、天津醫(yī)科大學(xué)碩士學(xué)位論文血清CEA、CYFRA211對(duì)非小細(xì)胞肺癌輔助化療患者的預(yù)后意義姓名：王曉東申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：臨床醫(yī)學(xué)；外科學(xué)胸外科指導(dǎo)教師：孫大強(qiáng)201205天津醫(yī)科大學(xué)碩士學(xué)位論文AbstractAbstract0bjective：TheaimofthisstudywastotestwhetherCEAorcyfra211isapredictivefactorforprognosisafteradjuvantchemo

2、therapyinnon——smallcelllungcallcerpatientsMethod：Thisstudywasaretrospectivestudy169nonsmalllungcancerWascollectedinourhospital，whohaveundergonecompleteresectionand2cyclesadjuvantchemotherapyAUcaseswereselectedatthesameti

3、memeetthefollowingrequirements：1completeresection(2005TheInternationalCommitteeofLungCancerStaging)；2AllcaseswereconfirmedbyabdominalCT，brainCTorMRI，boneECTandotherteststoexcludedistantmetastasis；3Allcases’stagewereIbIII

4、a(pTNM)；4Allcasesreceived刪uvantchemotherapywithin2monthsafteroperationsandthecyclesofadjuvantchemotherapy_2Theexclusioncriteriaofcases：1Malignancyhistoryincludinglungcancer；2Neoadjuvantchemotherapyorradiotherapybeforesug

5、ery；3RadiotherapyaftersurgeryThemedicinewasPlatinumcombinedwithGemcitabine／Paclitaxel／VinorelbineThedoseofthedrugs：GP(Gemcitabine10001250mg／m2，dl，d8；cis—platin75mg／mz，dlorcarboplatinAUC=5，d1TPpaclitaxel175200mg／mz，dl；cis

6、platin75mg／m2，dlorcarboplatinAUC=5，d1NPVinorelbine25mg／m2，dl，d8；carboplatin80mg／m2，d1Thechemotherapycycleswereatleast2ThemedicineWasPlatinumcombinedwithGemcitabine／Paclitaxel／VinorelbineThedoseofthedrugs：GP(Gemcitabine10

7、001250mg／m2，dl，d8；cisplatin75mg／m2，dlorcarboplatinAUC=5，d1TPpaclitaxel175200mg／m2，dl；cis—platin75mg／m2，dlorcarboplatinAUC=5，d1NPVmorelbine25mg／m2，dl，d8；carboplatin80mg／m2，d1Thechemotherapycycleswereatleast2Result：TheM曲le

8、velofCEA，CYFRA211after2cycles刪uvantchemotherapywerepoorprognosticfactorforOS，theriskratio(RR)was2003，1702respectivelyThehighCEAlevelWaSapoorprognosticfactor(RRl152)fortheDFSThemediansurvivaltime(MST)ofhi曲CEAlevelgroupWas