炔烴的高選擇性環(huán)加成反應(yīng)與金催化的3（2H）-呋喃酮構(gòu)建的新方法研究.pdf

1、河北師范大學(xué)碩士學(xué)位論文炔烴的高選擇性環(huán)加成反應(yīng)與金催化的3（2H）呋喃酮構(gòu)建的新方法研究姓名：劉美娜申請學(xué)位級別：碩士專業(yè)：無機(jī)化學(xué)指導(dǎo)教師：涂華民劉元紅20060501ABSTRACTIhlsartlclelsdlVldedIntotwOparts1)Transitionmetalmediatedinterorintramolecularcyclodimerizationofa(yneshasreceivedconsiderab】e

2、a￡tentiond嘶ngthelastseVera】decadesRecent赴‘organiczirconiumaspeculiarcharacterhasinducedaseriesofnewo唱anicreactionsinsynthesischemistryHowever，sofar，thetriplebondmoietyofalkynesusedincyclodimerizationreactionshasonlybeeni

3、ncorporajedinproductsasdoublebonds，andtherehasbeennoexampieinwhichoneofthetriplebondsisreducedtoasinglebond，thatis，theinformationofcyclobutenederiVatesHi曲lyregi—anddiastereoselectivetetrasubstitutedcyclobuteneswereacquir

4、edthroughthereactionof“Cp2Zr，’withheteroarylsubstitutedacetyIenesinthispaperThereactionconditionismoderateandtheyieidishighItaf如rdsanewreactionofzirconium—inducedcyclodimerizationofheteroaryl—substitutedalkynes】v工eanwh訂e

5、，wefoundthatthestablesubstitutedalkynespyrroIcanbeacquiredaccidentallywhichen“chedorganiczirconiumtransitionmetal一mediatedreactions2)The3(奶一furanonesareanimpor【a11tclassofheterocycliccompounds，whichareofphannacologicalsi

6、gnificanceandrepresentusefulbuildingblocksfornaturalproductssynthesesThesyntheticmet1。dsdeVelopedsofar，howeVer，haVesomedrawbacks，moreorless，suchaslackofsatisfactorygeneralpreparativeproceduresforstartingsubstratesDuetoth

7、eincreasedattentionofthisimponalltheterocycles，thereareneedstoenhancingtheemciencyofthesynmesisOfthesecompoundsandgeneratingthe3(2功一fmanoneswithawideVarietyofsubstituentsOntheotherhand，transition—metal—catalyzedheteroann

8、ulationreactionshaVebeendeVelopedwithremarkableimproVementsintemsofe伍ciencyand、videscopesofapplication，howeVer，thereisnoreponforconstructionof3(2印mranonesusingCransitionmetalmethodsWeareparticularlyinterestedinthetransit

9、ion—metalcatalyzedcyciizationofallenylketonesand3一alkyn一1一onesIthasrecentlybeenshownthatgold(III)saltsand901d(I)complexdisplayefkctiVecataIyticactiVityfbrthistypeofreactionduetotheexceIlentalkynophilicityofgoldwehaVesucc