3-氮雜雙環(huán)己烷衍生物及吡咯并喹啉類生物堿的合成.pdf

1、東北師范大學(xué)碩士學(xué)位論文3氮雜雙環(huán)己烷衍生物及吡咯并喹啉類生物堿的合成姓名：申美云申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：張前20080501AbstractModemdmgdiscoveryoReninVolVesscreeninglargequalltit)，ofsmaUmoleculesfortheirabilit)，t0bindtoapreselectedproteintargetAmongthesesmallmolecule

2、s，thealkaloidsshouldbetheoutstangdingone，becausemangofthemhaVeVerygoodpathologyactivi吼andalsomanyaregooddrugs3azabicyclo[310】hexanederiVatiVesisnotonlyabasicstmctureofbiologicallyactiVen叭mlproductssuchaSCC一1065，duoc鋤ycin

3、，aIldalsoa行鋤eworkofaph嬲nacogicallyimpoIrtantclaSsofcompoundssuchaS3，4memanoprolinesThepynoloquinolineringsystemhasa900dbiologicalactiVi瓢whichiskno、vnasacorestmctureunitofeithersynthetic0rnaturalsourceInourthesiswereporta

4、novelmethodforthesynthesisof3一azabicyclo[310]hexaneandpyrroloquinolineringderivativesInthefirstchapterweimroducedthebackgrolllldoftheresearchsimplyIntllesecondchapter、№haVedeVelopedanewonest印synthesisof3一azabicyclo【310】h

5、exanesfromreadilyaVailablepdicarbonylcompoundsand2，3dibromobutanamidesInmethirdchapterourinitinalstudieswerefocusedonsubstI鋮es謝tll3azabcyclo【310】hex鋤ecoreWestudytlleir肌herapplicationint11esynthesisofpyrroloquinolineringd

6、eriVatiVesundertheLewisacidmediatedreactioncondition111conclusion，wehavedevelopedanews仃ategyforthesynthesisof3一azabicyclo[310】hexanesandanemcient印proachforpyrrolo[3，2c】quinolines7nleadvantagesoftllissyntlleticroute，、Vhic