藥物分析期末復(fù)習(xí)資料

1、藥分期末復(fù)習(xí)（僅供參考）題型及分值一，寫出英文縮寫的全稱、中文10個(gè)2共20分二，單詞、詞組的英漢互譯5個(gè)2共10分三，問(wèn)答計(jì)算（inEnglish）5個(gè)4共20分四，單選20個(gè)1共20分五，名詞解釋10個(gè)2共20分六，計(jì)算2個(gè)5共10分一，寫出英文縮寫的全稱、中文10個(gè)2共20分GLP(GoodLabatyPractice)藥物非臨床研究質(zhì)量管理規(guī)范GMP(GoodManufacturePractice)藥品生產(chǎn)質(zhì)量管理規(guī)范GSP(G

2、oodSupplyPractice)藥品經(jīng)營(yíng)質(zhì)量管理規(guī)范GCP(GoodClinicalPractice)藥物臨床試驗(yàn)質(zhì)量管理規(guī)范QA(QualityAssurance)質(zhì)量保證QC（QualityControl)質(zhì)量控制UV（UltravioletSpectrophotometry）紫外光譜法IR(InfraredSpectrophotometry)紅外光譜法TLC（ThinlayerSpectrophotometry)薄層色譜法HP

3、LC(HighPerfmanceLiquidChromatography)高效液相色譜法GC(GasChromatography)氣相色譜法PC（PaperChromatography)紙色譜法FID(FlameIonisationDetect)氫火焰離子化檢測(cè)器FDA(FoodDrugAdministration)食品藥品監(jiān)督管理局SD(StardDeviation)標(biāo)準(zhǔn)偏差RSD(RelativeStardDeviation)相對(duì)標(biāo)

4、準(zhǔn)偏差LOD(LimitofDetection)檢測(cè)限LOQ(LimitofQuantitation)定量限Chp(PharmacopoeiaofThePeople’sRepublicofChina)中國(guó)藥典USP(UnitedStatesPharmacopoeia)美國(guó)藥典NF（NationalFmulary）美國(guó)國(guó)家處方集BP(BritishPharmacopoeia)英國(guó)藥典JP（JapanesePharmacopoeia)日本藥

5、局方二，單詞、詞組的英漢互譯5個(gè)2共10分LinearityRange線性和范圍Repeatabilityreproducibility可重復(fù)性和可重現(xiàn)性AccuracyPrecision準(zhǔn)確度和精密度StardOperationProcedure（SOP）標(biāo)準(zhǔn)操作程序Nonaqueoustitrations非水滴定Voidvolume死體積Capacityfact容量因子9WhatareprimarystardsPrimarystar

6、dsarestablechemicalcompoundsthatareavailableinhighpuritywhichcanbeusedtostardisethestardsolutionsusedintitrations.10WhatisBeerlambetlawA=ECLAistheabsbance.Eistheextinctioncoefficientoftheanalyte.Cistheconcentrationofthea

7、nalyte.Listhethicknessofthesolution11WhataretheComponentsofaUVvisspectrophotometerLamps、slit、monochromat、slit、quartzcell、detect124.2Whataretheconcentrationsofthefollowingsolutionsofdrugsing100mlmg100ml4.4Calculatetheperc

8、entageofstatedcontentofpromazinehydrochlideinpromazinetabletsfromthefollowinginfmation4.5Determinetheconcentrationofthefollowinginjections（答案見英文講義）13WhataretheComponentsofaHPLCsystemsolventreservoir→pump→injectionloop→co

9、lumn→UVvisdetect→integrat14Whatisthe‘Rfvalue’ofacompoundinaTLCchromatogramThedistancetravelledbythecompoundfromtheigin(wherethecompoundisputontotheplate)dividedbythedistancetravelledbythesolventfromtheiginiscalledthe‘Rfv

10、alue’ofthecompound.四，略(看原來(lái)的資料)五，略（看原來(lái)的資料）六，計(jì)算2個(gè)5共10分示例一茶苯拉明中氯化物檢查取本品0.30g置200ml量瓶中，加水50ml、氨試液3ml和10%硝酸銨溶液6ml，置水浴上加熱5min，加硝酸銀試液25ml，搖勻，再置水浴上加熱15min，并時(shí)時(shí)振搖，放冷，加水稀釋至刻度，搖勻，放置15min，濾過(guò)，取續(xù)濾液25ml置納氏比色管中，加稀硝酸10ml，加水稀釋至50ml，搖勻，在暗處放

11、置5min，與標(biāo)準(zhǔn)氯化鈉溶液(10μgClml)1.5ml制成的對(duì)照液比較，求氯化物的限量。C=10μgmlV=1.5mlS=0.325200示例三腎上腺素上酮體的檢查取本品0.2g置100ml量瓶中，加鹽酸溶液(92000)溶解并稀釋至刻度，搖勻，在310nm處測(cè)定吸光度不得超過(guò)0.05，酮體的百分吸收系數(shù)為435，求酮體的限量C=AE=0.05435=1.15104g100mlV=100mlS=0.2g1.取本品0.10g加鹽酸溶液