27109.免疫九肽質(zhì)量檢測方法的建立與穩(wěn)定性研究

1、西北大學碩士學位論文免疫九肽質(zhì)量檢測方法的建立與穩(wěn)定性研究姓名：程朋真申請學位級別：碩士專業(yè)：微生物指導(dǎo)教師：陳五嶺20100601StudyonQualityDetectionandStabilityofImmunityNinePeptideAbstractHyperglycemiaisasystemicdisease，whichmakeabnormalfatmetabolismoroperationoftheplasmaabovet

2、henormaloneoravarietyoflipidHyperlipidemiaisa11importantriskfactorfordiabetestopromotehighbloodpressureandimpairglucosetoleranceSearchforeffectivedrugtreatmentofhyperlipidemiaisamajortopicofcurrentresearchThepurposeofthi

3、spaperistogetphysicalandchemicalpropertiesandcontrolqualityoftheprocessoftheirproductionthroughexperimentalresearchofImmunityninepeptideAccordingtotheguidingprinciplesofdrugpharmaceuticalresearchtechniquesandchemicalstab

4、ilitystudiesontechnicalguidelines([HIGPH61)andtheChinesePharmacopoeia(2005edition)，referencematerialsanddesignfeaturesofninepeptides謝tllimmunizationexperiments，theexperimenttookasystematicstudyonqualitynatureanddetection

5、indicatorsoftheImmunityninepeptidemedicineThroughtheanalysisofthenatureoftheImmunityninepeptide，madethedetectionindicatorsandestablishedthedetectionwayforImmunityninepeptideandfinallytookqualitydetectionwinlthepeptideacc

6、ordingtotheformerwayFirst，thisstudyestablishedadetectionmethodforimmunityninepeptidewithhighperformanceliquidchromatography(RPHPLC)，bytheseparationofitsproprietaryexperimentalandmethodologicalvalidation，aswellaslinearand

7、scopeoftheinvestigation，Theresultsshowthatthemethodusedfordetectionofimmuneninepeptide，hasagoodsystemapplicabilityoftheworkoflinearityspecificitysensitivityandstabilityAndthenusedhighperformanceliquidchromatography(RP—HP

8、LC)toanalyzetrifluoroaceticacidresiduesandrelatedsubstances，andafteraseptictesting，weinspectedthequalityofproductsInthelastpart，thestabilitystudies，whichcontainthetestofimpactfactorsintheconditionofthelighthightemperatur