慢性強迫游泳對大鼠行為學及腦內(nèi)PSD-95表達的影響.pdf

1、福建醫(yī)科大學碩士學位論文慢性強迫游泳對大鼠行為學及腦內(nèi)PSD95表達的影響姓名：鄭金熾申請學位級別：碩士專業(yè)：精神病學與精神衛(wèi)生指導教師：林賢浩20100501Chronicforcedswimming’SimpactonethologyandtheexpressionofPSD95ofthebraininratsobjective1Toestablishratmodelofchronicforcedswimmingsuccessful

2、ly；2，Toobservechronicforcedswimming’Simpactonbiological，behavioral，psychologicalofrats；3，Toobservechronicforcedswimming’SimpactontheexpressionofPSD95inhippocampus，prefrontalcortexandbasalgangliaofrats；4，Toobservetheeffec

3、tandanalysisthemechanismofMK801MethodsTheratmodelofchronicforcedswimmingisestablishedRandomlyratsweregroupedintocontrolgroup(C)，simplestressgroup(M)，interventiongroup(T)Weightsofratsweremeasuredonthe1st，6th，10th，14thdaya

4、fterchronicforcedswimming；Sugarconsumptionexperimentwasdoneontheforthweek；1％sugaranddrinkingwaterconsumptionwasobservedinratsLiquidconsumptionofratsofdifferentweightswereassessedbytherelativeconsumptionImmobiledtimeofeac

5、hratwascalculatedasbehavioralindicators。胎sternBlotmethodwasusedtodetecttheexpressionandchangesofPSD95inhippocampus，prefrontalcortexandbasalgangliaofratsofeachgroupResults1，Afterforcedswimming，comparedwiththecontrolgroup，

6、thegrowthofwageWassloweronthe14thdaytheimmobiledtimewasnotsignificantlydifferentamongthe2ndand4thdaytheimmobiledtimewaslongeramongthe5thand14thdaytheexpressionofpsd95washigherinthehippocampus，prefrontalcortexandbasalgang

7、liaAfterforcedswimming，comparedwiththe1stdaytheimmobiledtimewaslongeramongthe2ndand14thday2，AfterinjectedMK801，comparedwiththesimplestessgroup，thegrowthofwagewasmoreobviousonthe14thdaythewatercomsuptionWasmoreimcreased，t