肺腺癌中K-ras基因突變及血管內(nèi)皮因子的表達(dá)的臨床意義及其相關(guān)性分析.pdf

1、蘇州大學(xué)碩士學(xué)位論文肺腺癌中Kras基因突變及血管內(nèi)皮因子的表達(dá)的臨床意義及其相關(guān)性分析姓名：孟玲申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：內(nèi)科學(xué)指導(dǎo)教師：馬家用20021001赫赫癌串Kras基戮突變及盤管雨寂鞭子靜表達(dá)鰉睡霖爨義及其相關(guān)穗努輯英文攘要ThemeaningofKrasgenesmutationsandtheexpressionofvasculerendothelialgrowthfactor(VEGF)innonsmalledllung

2、cancersandtheirrelationsAbstractobjeetive：ToinvestigateKrasgenesmutationsandtheexpressionofvasculerendothelialgrowthfactor(VEGF)innonsmallcelllungcancersandtheirrelationswithkindsofpathologicaltargets：age，sexandphase。Mea

3、nwhile，toanalyzetheassociationbetweenK—rasgenesmutationsandtheexpressionofvasculerendothelialgrowthfactor(VEGF)innonwsmallcelllungcancersMethods：Thesamplesof33patientswitllprimarynon—smallcelllungcancersand7patientswitho

4、utlungcancersweremeasuredbySPimmunohistochemicalstudiesResults：(1)TheexpressionsofK—rasgenesmutationsandVEGFingroupswithlungcancerswerehigererthanthoseincontrolgroups。(2)Therewere14tumorsgradedaspositivetumorsand9negativ

5、estainingaboutK—rasgenesmutationsingroupswithlymphnodemetastasisHowevertherewere2tumorsgradedaspositivetumorsand8tumorsgradedasnegativestainingaboutK—rasgenesmutationsingroupswithoutlymphnodemetastasis(3)Therewere19VEGF—

6、positivetumorsand4VEGF—negativetumorsingroupswithlym瑟nodemetastasisHowevertherewere3VEGFpositivetumorsand7VEGF—negativetumorsingroupswithoutlymphnodemetastasis。(4)AbouttherelativeanalysebetweenkrasgenesmutationsandVEGFin