亞低溫對(duì)重癥高血壓腦出血細(xì)胞凋亡的影響.pdf

1、Objective To observe the change of the soluble form of the Fas in CSF andneuron-specific enolase in serum of patient with hypertensive cerebral hemorrhage and tofind mild hypothermia effects on apoptosis and necrosis of

2、 in treating severehypertensive cerebral hemorrhage.Method A total of 18 patients with hypertensive cerebral hemorrhage were dividedinto 2 groups,mild hypothermia group(MHTG ,9 cases) and conventional therapeuticgroup

3、(CTG, 9 cases).In MHTG ,mild hypothermia was performed in 24 hours afterintracerebral hemorrhage.The treatment durations were 24 to72 hours for the patients ofrectal temperature kept at 33℃～35℃.In CTG conventional drugs

4、were administrated. Weexamined the levels of the soluble form of the Fas(sFas) in the cerebrospinal fluids(CSF)and leves of neuron-specific enolase(NSE) in serum.of patients with cerebral hemorrhageusing an enzyme-linked

5、 immunosorbent assay(ELISA). Comparison analyse wereperformed by a SPSS 13 statistical package.Results The concentrations of aFas were significantly elevated and reached thehighest level at about 48～72 hour after ICH, T

6、he concentrations of aFas in the MHTGgroup were lower than the CTG group.(P＜0.05).The concentrations of NSE were higherin patients with ICH and peaked at 1st day after hemorrhage and gradually decrease, Theconcentration

7、s of NSE in the MHTG group were lower than the CTGgroup.(P＜0.05).There was no correlation between the concentrations of aFas in CSF andthe CSF/serum albumin quotient.(P＞0.05) the CSF/serum albumin quotient in t

8、he MHTGgroup were lower than the CTG group.(P＜0.05).Conclusion (1)There are primary injury and secondary neuron injury after ICH,(2)The Fas/FasL system play an important role in secondary injury and sFas may prohibitneur