DL—色氨酸的化學(xué)合成及其拆分.pdf

1、東南大學(xué)碩士學(xué)位論文DL—色氨酸的化學(xué)合成及其拆分姓名：劉紅利申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：張征林鄒建忠20040401東南大學(xué)碩士學(xué)位論文AbstractD—tryptophan，anon—proteinopticallyactiveaminoacid，hasbeenextensivelyusedasmedicalsemiproduct，non—nutrientsweetagent，feedstuffaddhives，pl

2、antsgrowthadditives，soresearchonsynthesisofD—tryptophanisofgreatsignificancebothintheoreticalandinpracticalsideInthispaperDL—tryptophanracemateissynthesizedinachemicalwayandthenDtryptophanisobtainedbychemicalresolutionDL

3、tryptophanissynthesizedusingphenylhyarazineasrawmaterialbyaddition，condensation，cyclization，hydrolysis，decarboxylation，rehydrolysisandotherprocessesinthispaperGeneralyieldis436％withgoodpuritythatismorethan990％Muchworkhas

4、beendoneintheoptimizationofsynthesisparametersofDL—tryptophanInthispapertheoptimaltechnicalparameterswerefoundfofthesynthesisofDLtryptophanParallelexperimentswerecarriedoutwithquitestableresultsandgoodrepeatibilityFinalp

5、roductwascharacterizedbymeltingpointdetermination，HPLC，elementanalysisandIRspectrometerDL—tuptophanisresolvedbyDcamphorsulphonicacidasresolutionagentThechemicalresolutionconsistsoftwosteps：fit3t，saltofD—tryptophanD—camph

6、orsulphonatewasseparatedfromsaltofLtryptophanDcamphorsulphonateusingthedifferenceoftwosailsinsolubilityandthenfinalopticallyactiveDtryptophanwasacquiredbyhydrolysisandpurificationofthemothersaltForthismethod，generalyield

7、ofDtryptophanwhosepurityismorethan987％is398％withopticalpuritymorethan980％InthispaperflaeoptimalresolutionparametersofDL—tryptophanwerealsodeterminedIneverystepOfreaction，theresultantsemiproductwasanalyzebymeltingpointdet

8、ermination，rotation，IRspectrometerHPLC，elementanalysisandH’NMRMechanismofformationofDL—tryptophan，ofresolutionofDLtryptophanusingD—canaphorsulphonicacid，ofpurificationofD—tryptophanbyisoelectricpointmethodandofracemizati