pH敏感羥丙甲基纖維素衍生物的合成及其性質(zhì)研究.pdf

1、河南大學(xué)碩士學(xué)位論文pH敏感羥丙甲基纖維素衍生物的合成及其性質(zhì)研究姓名：陳建黨申請學(xué)位級別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：余學(xué)軍20090501河南大學(xué)碩二I：研究生學(xué)位論文(2009)AbstractThin—filmcoatingtechnologyiscommonlyusedinthecontrolledorsustainedreleaseoforaldrugsInrecentyears，Ithasalsobeenusedforco

2、lon—specificdrugdeliverytoimprovethetreatmenteffectsofcolondiseases，teducesystemicsideeffects，toavoidthedrugs，suchasproteinpeptide，beingdestructedinthegastro—intestinaltractandhenceimprovetheirbioavailabilityInthisthesis

3、，pHsenstiveshydroxypropylmethylcellose(HPMC)derivativesweredesignedandsynthesizedforuseasnoveloralcolonspecificcoatingagentsTwotypesofHPMCwerechemicallymodified，usingaceticanhydride(AA)andtetrahydrophthalicanhydride(THPA

4、)ormethyltetrahydrophthalicanhydride(MTHFA)orhexahydrophthalicanhydride0qmA)ormethylhexahydrophthalicanhydride(MHHPA)ornadieanhydride甜A)，toobtainpH—sensitivepolymers，hydroxypropylmethylcelloseacetatetetrahydrophtalate(HP

5、MCATH)，hydroxypropylmethylcelloseacetatemethyltetrahydrophtalate(HPMCAMT)，hydroxypropylmethylcelloseacetatehexahydrophthalate(HPMCAHH)，hydroxypropylmethylcelloseacetatemethylhexahydrophthalate(HPMCAMH)，hydroxypropylmethy

6、lcelloseacetatenadicate(HPMCANA)Thenewpolymerswerecharacterizedbyinfraredspectroscopy，determinationofacetylcontentandacidvalueTheirpharmaceuticalproperties，such舔pH—sensitivevalues，watervaporpermeabilitytensilestrengthand

7、glaSstemperature(Tg)，wereinvestigatedandcomparedwiththoseofmethylcelluloseacetatesuccinate(HPMCAS)ThestructurepropertyrelationshipWaspreliminarilydiscussedHPMCAMT15，HPMCAP10andHPMCANA10havegoodfilm—formingnatureTheirpHse