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1、EDITEDBYSTENRENIUS?LESTERPACKER?ENRIQUECADENASEDITEDBYSTENRENIUS?LESTERPACKER?ENRIQUECADENASMITOCHONDRIALSIGNALINGINHEALTHDISEASEMITOCHONDRIALSIGNALINGINHEALTHDISEASEBIOLOGYISBN:9781439880029978143988002990000K13756Cover

2、image:CourtesyofDr.LucaScrranoUniversityofGeneva.Thepicturerepresentsa3DreconconstructionofthemitochondrialwkinamurineembryonicfibroblastexpressingOPA1aftertransfectionwithmitochondriallytargetedEYFP.Mitochondriahavetrad

3、itionallybeenassociatedwithmetabolicfunctionshoweverrecentresearchhasuncoveredacentralroleftheseganellesincellsignalingcellsurvivalcelldeath.Mitochondrialdysfunctionisafactinmyriadpathophysiologicalconditionsincludingage

4、relatedneurodegenerativedisderscancermetabolicsyndromecardiovulardisease.MitochondrialSignalinginHealthDiseaseexaminesthemesessentialfthemaintenanceofthemitochondrialredox(reductionoxidation)energyaxis.Withcontributionsf

5、romanimpressivecadreofinternationallyrecognizedscientiststhebookdiscussescodinatedmitochondrialfunctionsthatregulatecellfunctionbydiscretesignalingpathways.Topicsdiscussedinclude?Electrontransptenergyproduction?Mitochond

6、rialbiogenesisdynamics?Mitochondrialsignaling?Apoptosisautophagy?Pharmacologysignaling?Epigeicsignaling:mitochondrialmethylationacetylationreactionsAnessentialresourceflifehealthscientistsaswellaspharmaceuticalindustrypr

7、ofessionalsthisvolumehighlightstheimptanceofmitochondrialsignalingitsroleinestablishingharmonizedcommunicationbetweenseveralcellularcompartments.Theinfmationinthisvolumeiscriticaltothosedevelopingmitochondriontargetedthe

8、rapiesaimedatassuagingmitochondrialdysfunctionthespecificfactscontributingtoitsdysfunction.MITOCHONDRIALSIGNALINGINHEALTHDISEASEMITOCHONDRIALSIGNALINGINHEALTHDISEASERENIUSPACKERCADENASRENIUSPACKERCADENASK13756_Cover_mech

9、.indd1511122:24PM1.OxidativeStressinCancerAIDSNeurodegenerativeDiseaseseditedbyLucMontagnierRenOlivierCatherinePasquier2.UnderstingtheProcessofAging:TheRolesofMitochondriaFreeRadicalsAntioxidantseditedbyEnriqueCadenasLes

10、terPacker3.RedoxRegulationofCellSignalingItsClinicalApplicationeditedbyLesterPackerJunjiYodoi4.AntioxidantsinDiabetesManagementeditedbyLesterPackerPeterRsenHansJ.TritschlerGegeL.KingAngeloAzzi5.FreeRadicalsinBrainPathoph

11、ysiologyeditedbyGiuseppePoliEnriqueCadenasLesterPacker6.NutraceuticalsinHealthDiseasePreventioneditedbyKlausKrmerPeterPaulHoppeLesterPacker7.EnvironmentalStresssinHealthDiseaseeditedbyJrgenFuchsLesterPacker8.HbookofAntio

12、xidants:SecondEditionRevisedExpededitedbyEnriqueCadenasLesterPacker9.FlavonoidsinHealthDisease:SecondEditionRevisedExpededitedbyCatherineA.RiceEvansLesterPacker10.Redox–GenomeInteractionsinHealthDiseaseeditedbyJrgenFuchs

13、MaurizioPoddaLesterPacker11.Thiamine:CatalyticMechanismsinNmalDiseaseStateseditedbyFrankJdanMulchS.Patel12.PhytochemicalsinHealthDiseaseeditedbyYongpingBaoRogerFenwick13.CarotenoidsinHealthDiseaseeditedbyNmanI.KrinskySus

14、anT.MayneHelmutSies14.HerbalTraditionalMedicine:MolecularAspectsofHealtheditedbyLesterPackerChoonNamOngBarryHalliwellOXIDATIVESTRESSDISEASESeriesEditsLesterPackerPhDenriquecaDenasMDPhDUniversityofsoUthernCalifniasChoolof

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