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1、石河子大學(xué)碩士學(xué)位論文VEGF及uPA在腦腫瘤的表達(dá)與臨床意義姓名：王業(yè)忠申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：外科學(xué)指導(dǎo)教師：彭心宇徐啟武20050501VEGFanduPAexpressioninBrainTumoranditsClincalSignificancePostgraduate：WangYeZhong(Surgery)Advisor：ProfessorPenXinYuProfessorXuQiWuobjeet：Intrcraniall

2、ulnorisacommondiseaseinneurosurgeryofwhichmeningiomagliomametastaticbraintumoraccountforover60％AlthouIghtherecentimagingtechnologicaladvanceandmicrosurgeryhaveimprovedthediagnosisandtreatmentoftheforegoingbraintumorssome

3、problemsstillremainThedeterminationandapplicationofsuchprognosticindexesascerebromasoakagerecurrenceandcancerometastasisisthemajorprobleminclinicalpracticeRecentlymolecularbiologicalstudyonintracranialprimarytumorandmeta

4、statictumorshowsthatprognsisofbraintumoriscloselyassociatedwithvascualrendothelialgrowthfactor(VEGF)andurokinasetypeplasminogenarctivextor(uPA)inaddhinntoclinicalstage，pathologicalgradingandpefitumoralbrainedemaLittieres

5、earchhasbeendoneinthisfieldalthoughtherearesomerelevantrepots，thisstudychoosesintracranialprimaryandsubsequent，benignandmalignantmeningioma，gliomametastaticbraintumorwhosewaysofgrowthvarybutarerepresentativeTherelationbe

6、tweentheirVeGFanduPAexpressionandtheirclinicalpathologyandperitumoraledemaaredetectedandcheckedinordertoprovideguidanceforclinicaltreatmentorprognosisMethod：100patientswithmaningioma(30CaseS)，metastaticbrainturnor(30case

7、s)and40patientswithgiiomawerehospitalizedinthedepartmentofneurosurgeryfromOct，1998toOct2004AllthecaseswerediagnosedaccuratelybytwopluspathologistsAccordingtoWHOGliomaGrading8CaSeswereIgrade，12casesIIgrade，10CaSeSIIIgrade

8、and10casesIVgrade100patientswerefollowedbyfollow—upstudy(in6years)1mmunohisologicalchemicaldyewasappliedtoallthetissuestobecheckedusingstreptavidinPeroxidasemethod(SPmethod)Thedeggreeofperitumoralbrainedema口TBE)wasestima

9、tedonthebasisofCTofheadand／vlRITheresultsofallthegroupswereanalyzedstatisticallyResults：Among100patientswitlbratntumorthetotalpositiverateofVEGFwhenimmanohistologicalchemicaldyewasappliedwas90％(90／100cases)whilethepositi

10、verateofVEGFwas7667％formeningioma，95％forgiiomaand9667％formetastaticbraintnlnorrespectivelyThetotalpositiverateofuPAwhenimmanohistologicalchemicaldyewasappliedwas91％(91／100cases)whilethepositiverateofuPAwas8333％formeningi

11、oma925％forgliomaand9667％formetastaticbraintumorrespectivelyThepositiverateofVEGFanduPAforgliomaandmetastaticbraintumorissignificantlyhigherthanthatofVEGFanduPAformenin舀omaandtheshowisconsistentineachtulnorVEGFanduPAcould

12、notshowin10casewithouttumorinvolvementsandnormalbraintissuesTheshowofVEGFanduPAisposisfivelycorrelatedwiththemalignancelevelofgiiomaTheshowofVEGFanduPAislowerinlowgradedgliomaandhigherinhigllgradedgliomaTheVEGFshow(50／d3

13、5％)anduPAf5％／40％showoflowgradadgliomaandhighgradedgiiomawereshowedpositivelyandshowedsignificantdifierenceBrainedemawasmostobviousinpatientswithmetastaticbraintumorlessobvinusinpatientswithgliomaandleastobviousinpatients

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