阿米替林對雌二醇誘導(dǎo)的大鼠多囊卵巢模型卵巢功能和去甲腎上腺素受體的影響.pdf

1、蘭州大學(xué)碩士學(xué)位論文阿米替林對雌二醇誘導(dǎo)的大鼠多囊卵巢模型卵巢功能和去甲腎上腺素受體的影響姓名：張磊申請學(xué)位級別：碩士專業(yè)：生物學(xué)、動物學(xué)指導(dǎo)教師：王建林崔勝20100501。：鄉(xiāng)麓粥步旁碩士學(xué)位論文AbstractThestudyaimistoevaluatetheinfluenceofTricyclicantidepressantsffCAs)，Amtriptyline(AMI)，toovariesofthePCOSpatients

2、whotakeitchronicallyWeuseEVtoinduceratPCOmodel，whichreflectssomeendocrinologicandmorphologicalcharacteristicsofhumanPCOS，anditisassumedthatactivityintheovariansympatheticnervesismorelivelyInthepresentstudytodeterminether

3、oleofamitriptylineinthemRNAsexpressionofovarianalphala，lb，ldandmRNAandproteinexpressionB2ARs，andovarianmorphologybyintraperitonealinjectionsofamitriptylineinthedevelopmentofEVinducedPCOTheresultincludesthefollowingpoints

4、1Thecontrolgroupratsdisplayedaregular4dayestrouscycleEstrouscyclicitywasunaffectedintheAMIgroupInthePCOgroup，estrouscyclicitywasdisruptedwithpersistentestrusphasesThedisruptedestrouscyclewaspartiallyrestoredinthePCOAMlgr

5、oupwheretheratsunderwentdiestrusphasesofthecycle2OvarianweightinthePCOgroupwassignificantlylowerthaninthecontrolgroups，andA／VIItreatmentincreasedtheweightoftheovaryTheovariesintheControlandAMIgroupswerenormalinappearance

6、，withlargecorporaluteaandfolliclesindifferentstagesofgrowthandregressionTheovariesinboththePCOandthePCO屯氣MIgroupsdisplayeddecreasedovariansizeaswellasadecreaseinnumberandsizeofthecorporaluteacomparedwiththeovariesintheCo

7、ntrolgroupThecorporaluteainthePCOAMlgroupwereslightlylargerthaninthePCO，andthenumbersweremore，andthereweremore“healthy”nonatreticfollicles3ExpressionsmRNAofaaARandB2ARwasunchangedinthePCOgroupcomparedwiththecontrolgroupA

8、mitriptylinetreatmentdidnotalterthemRNAexpressionofan—ARandB2ARinPCOratsTheexpressionofabARandadARmRNAweresignificantlyhigherinthePCOgroupcomparedwiththeControlgroupThemRNAexpressionofabARandadARintheovariesofPCOratsthat