可溶性細(xì)胞間粘附分子-1（sICAM-1）在兒童自身免疫性甲狀腺疾病中的變化和作用.pdf

1、華中科技大學(xué)同濟(jì)醫(yī)學(xué)院碩士學(xué)位論文可溶性細(xì)胞間粘附分子1（sICAM1）在兒童自身免疫性甲狀腺疾病中的變化和作用姓名：吳莉申請學(xué)位級別：碩士專業(yè)：兒科指導(dǎo)教師：林漢華2002.4.1蘭主!!墊奎蘭墮塑墮蘭墮堡：!!塑生蘭、業(yè)堡苧Solubleintercellularadhesionmolecule(slCAM1)inseraofpatientswithautoimmunethyroiddiseasesPostgraduateWuLiD

2、irectorLinHanhuaABSTRACTOBJECTIVEInordertostudythepossibleroleofthesolubleintercellularadhesionmolecule(slCAM1)inautoimmunethyroiddiseases(AITD)，wemeasuredthechangesofslCAM1levelsintheseraofpatientswitllHashimoto’Sthyroi

3、ditis(HT)andGraves’disease(GD)METHODAlloftheserawerecollectedfromtheuntreatedpatientswitllthyroidgoiterinoutpatientclinic，andwereclassifiedasfollows：groupA，10untreatedhyperthyroidpatients；groupB，14untreatedhypothyroidpat

4、ients；groupC，22euthyroidpatients；andacontrolgroupof10healthychildrenSICAM1levelsweremeasuredbyasandwichlinkedimmunosorbentassay(ELISA)methodComparedwiththyroidfunction、fineneedleaspirationcytologyofthyroidandslCAM一1level

5、saftertreatmentofthosepatients，therolesinimmunopathologyofslCAM一1inAITDwereanalyzed1iESULTSComparedwithcontrols，slCAM一1levelsweremarkedlyelevatedinuntreatedpatientsingroupAandB，especiallyingroupA；ingroupC，twogroupsofdata

6、wereobservedwithgreatdistinctnessgroupwithelevatedslCAM一1levelsandgroupwitllnormalslCAM1levelsAftertherapyadecreaseofslCAM一1levelscouldbeobservedinbothgroupAandBAndwithinthegroupA，slCAM1levelsofpatientswithaphthalmopathy