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1、1800 英文單詞, 英文單詞,9300 英文字符,中文 英文字符,中文 2650 字文獻(xiàn)出處: 文獻(xiàn)出處:Miyauchi Y, Horiguchi T, Ishizawa H, et al. Blood glucose level measurement by confocal reflection photodetection system[C]//SICE Annual Conference 2011. IEEE, 2011:
2、 2686-2689.英文原文Blood Glucose Level Measurement by Confocal Reflection Photodetection SystemYuki Miyauchi,Takuro Horiguchi, Hiroaki Ishizawa, Shin-ichirou, Hitoshi Hara5AbstractIn the present study, the confocal optical s
3、ystem has been constructed by using the near-infrared laser, and the reflection photodetection system of the living body has been developed. This system reduces the influence of a complex light scatter by the skin tissue
4、 and achieves a highly accurate measurement by confocal optical system. And the initial experiment for the development of the non-invasive blood glucose meter that presumed the blood glucose level by thenear-infrared abs
5、orption of the living body has been done. In this report, the principle of the blood glucose level measurement of this system has been confirmed. The light intensity of the reflection in the living body skin tissue has b
6、een measured in the constructed system, and it has been compared with the blood glucose level reference value. As a result, the absorption of the reflected light that depended on the blood glucose level has been confirme
7、d. The possibility of measuring the blood glucose level has been shown. Keywords: Confocal Optical System, Non-invasive, Blood Glucose, Near-infrared. 1. INTRODUCTIONRecently, the diabetic increases remarkably [1, 2]. Th
8、e self-monitoring of blood glucose (SMBG) is necessary and indispensable to treat the diabetic. However, present SMBG has been limited to the measurement that needs collecting blood. The patient has loads of pain, stress
9、, and costs, etc. Therefore, the non-invasive blood glucose meter to be able to measure the blood glucose level is strongly expected [3-5]. In the present study, the confocal optical system has been constructed by using
10、the near-infrared laser, and the reflection photodetection system of the living body has been developed. And the initial experiment for the development of the non-invasive blood glucose meter that presumed the blood gluc
11、ose level by the near-infrared absorption of the living body has been done. This system reduces the influence of a complex light scatter by the skin tissue and achieves a highly accurate measurement by confocal optical s
12、ystem [6, 7]. In this report, the focus depth by the confocal optical system of this system has been confirmed. And the principle of the blood glucose level measurement of this system was confirmed. The light intensity o
13、f the reflection in the living body skin tissue has been measured in the constructed system, and it has been compared with the blood glucose level reference value. As a result, the absorption of the reflected light that
14、depended on the blood glucose level has been confirmed. The possibility of measuring the blood glucose level has been shown. Fig. 3 Appearance of a living body blood glucose level measurement2.2 Polycarbonate plate measu
15、rement The polycarbonate plate was set up in the vicinity of the focus of object lens. The thickness of the polycarbonate plate is 5.0 mm and refractive indexes are n = 1.5. The focus of object lens from the sample surfa
16、ce side to the bottom side was scanned at intervals of 0.1 mm, and the reflected light of each point was acquired. The aluminum plate was set up in the polycarbonate plate bottom as a reflector. When measuring it, the st
17、ate to remove the confocal pinhole to compare it with the image optics system was measured. 2.3 Living body blood glucose level measurement The present study was approved because of regulations of the Shinshu University
18、ethics committee. And it won consent from the subject by the document. The relation between the amount of near-infrared absorption measurements of this system and the reference value that depended on the living body bloo
19、d glucose level was examined. The measuring object was made a palmar side of the left hand thumb root. The depth of the measurement skin tissue was assumed to be 0.5 mm, 1.0 mm, 1.5 mm, and the surface. And the living bo
20、dy was made to stick to the window material of this system, and the reflection light intensity in each depth was measured. Moreover, the blood glucose level reference value was measured by the enzyme electrode method at
21、the same time. A male in his twenties and an able-bodied person were made a subject. They were measured twice when they were hungry, and they were measured 9 times at intervals of 5 minutes after glucose load. 3. EXPERIM
22、ENTAL RESULT3.1 Reflection light intensity through the polycarbonate plate Fig. 4 showed the reflection light intensity in each point from the vicinity of the surface of the polycarbonate plate to the bottom. The peak of
23、 the scanning distance about 4.8 mm is a reflected light of the sample bottom. And it was confirmed by both of the image optics system and the confocal optical system. Moreover, the reflected light on the sample surface
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