過敏性紫癜兒童急性期血漿白細(xì)胞介素13、15水平的變化及意義探討.pdf

1、Objective To probe the changes and clinical significances of interleukin-13 and interleukin-15 in children with Henoch-Schoenlein purpura(HSP).Methods Plasma IL-13 and IL-15 were detected in 61 children with HSP in acu

2、te phase and 25normal children by ELISA.The level of plasma IL-I 3 and IL-15 in different clinical categories of HSP were compared. Results ①Plasma IL-13 levels in children with HSP in acute phase[ (4.8±3.1) pg/ml]

3、 were significantly higher than those in healthy controls[ (2.0 ±1.6) pg/ml](t=4.28,P＜0.01 ); plasma IL-13 levels in patients with or without renal involvement of HSP[ ( 7.5 ± 5.9 ) pg/ml、 ( 3.2 ± 2.5 ) pg/ml] were all s

4、ignificantly higher than those in healthy controls (F=53.92, p＜0.01;q=13.87, 3.40, p＜0.01 or 0.05 ); the plasma IL-13 levels in patients with renal involvement were significantly higher than those of without renal involv

5、ement (F=53.92, p＜0.01 ;q= 11.86, p＜0.01 ).②Also,plasma IL-15 levels of HSP group[ ( 17.5 ± 10.2) pg/ml] are significantly higher than those of controls[ ( 4.2± 3.5 ) pg/ml] (t=6.34, P＜0.01 )； both plasma IL-15 levels wi

6、th and without renal involvement[ (29.1± 16.5)pg/ml、 (10.5±7.4) pg/ml] were significantly higher than those in healthy controls(F=40.45, p＜0.01;q=12.18, 3.46, p＜0.01)； the plasma IL-15 levels in patients with renal invol

7、vement were significantly higher than those of without renal involvement (F= 4 0.4 5, p＜0.01;q= 9.9 5, p＜0.01 ). Conclusions Plasma IL-13 and IL-15 levels in acute phase of HSP significantly increased, and the levels

8、 in patients with renal involvement were significantly higher than those of without renal involvement. These results suggested that IL-13 and IL-15 play a crucial role in pathogenesis of HSP. The plasma IL-13 and IL-15 l